Biology

We are broadly interested in the molecular mechanisms underlying skeletal muscle formation, degeneration, and regeneration. We also have a growing interest in the biology of the myotendinous junction. Current projects focus on the spatiotemporal regulation of proteases and focal adhesion proteins. We utilize a diverse set of model systems, including C2C12 cells, primary myoblasts, patient-derived iPSCs/fibroblasts, and zebrafish.

Technology

We employ multiple existing and new chemical biology techniques in addition to standard molecular approaches. For example, we are leveraging activity-based proteomics and N-terminomics to identify and understand proteolytic switches involved in myogenic differentiation. We are also developing an interactome mapping platform for zebrafish and mammalian tissues that does not require any genetic manipulation.